Dr. Heather Acuff publishes her article "Association of Neuroimaging Measures of Emotion Processing and Regulation Neural Circuitries With Symptoms of Bipolar Disorder in Offspring at Risk for Bipolar Disorder," in JAMA Psychiatry. She concludes "To our knowledge, this is the first study to use both cross-sectional and longitudinal analyses of emotion processing and regulation neural circuitries in youth at risk for BD vs comparative at-risk and healthy control groups. We show that greater right rACC activity to happy faces and greater amygdala to left cACC functional connectivity to fearful faces during attentional task performance with high memory load conditions significantly distinguish OBP from OCP, at the group level, and these measures have significant associations with affective lability, a precursor of BD. We conclude that greater right rACC activity and greater amygdala to left cACC functional connectivity during emotional regulation are candidate objective markers of BD risk in youth. Our findings are important steps toward identifying neural markers of BD risk to aid in enhanced early identification and guide interventions for BD at-risk youth."
Dr. Acuff publishes in JAMA Psychiatry