johnathon vande geest

  • Professor and Director of PhD Admissions

Education & Training

  • PhD, Bioengineering, University of Pittsburgh, 2005
  • BS, Biomedical Engineering, University of Iowa, 2000

Representative Publications

Furdella, K.J., Higuchi, S., Behrangzade, A., Kim, K., Wagner, W.R., & Vande Geest, J.P. (2021). In-vivo assessment of a tissue engineered vascular graft computationally optimized for target vessel compliance. ACTA BIOMATERIALIA, 123, 298-311.Elsevier BV. doi: 10.1016/j.actbio.2020.12.058.

Liou, J.J., Drewry, M.D., Sweeney, A., Brown, B.N., & Vande Geest, J.P. (2020). Decellularizing the Porcine Optic Nerve Head: Toward a Model to Study the Mechanobiology of Glaucoma. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 9(8), 17.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/tvst.9.8.17.

Liou, J.J., Shoemaker, J.E., & Vande Geest, J.P. (2020). Mechanobiology of the Optic Nerve Head in Primary Open-Angle Glaucoma. In Mechanobiology. (pp. 47-64).Elsevier. doi: 10.1016/b978-0-12-817931-4.00003-0.

Ardila, D.C., Liou, J.J., Maestas, D., Slepian, M.J., Badowski, M., Wagner, W.R., Harris, D., & Vande Geest, J.P. (2019). Surface Modification of Electrospun Scaffolds for Endothelialization of Tissue-Engineered Vascular Grafts Using Human Cord Blood-Derived Endothelial Cells. JOURNAL OF CLINICAL MEDICINE, 8(2), 185.MDPI AG. doi: 10.3390/jcm8020185.

Ardila, D.C., Tamimi, E., Doetschman, T., Wagner, W.R., & Geest, V.J.P. (2019). Modulating smooth muscle cell response by the release of TGF beta 2 from tubular scaffolds for vascular tissue engineering. JOURNAL OF CONTROLLED RELEASE, 299, 44-52.Elsevier BV. doi: 10.1016/j.jconrel.2019.02.024.

Behkam, R., Kollech, H.G., Jana, A., Hill, A., Danford, F., Howerton, S., Ram, S., Rodriguez, J.J., Utzinger, U., Girkin, C.A., & Vande Geest, J.P. (2019). Racioethnic differences in the biomechanical response of the lamina cribrosa. ACTA BIOMATERIALIA, 88, 131-140.Elsevier BV. doi: 10.1016/j.actbio.2019.02.028.

Kollech, H.G., Ayyalasomayajula, A., Behkam, R., Tamimi, E., Furdella, K., Drewry, M., & Geest, J.P.V. (2019). A subdomain method for mapping the heterogeneous mechanical properties of the human posterior Sclera. Frontiers in Bioengineering and Biotechnology, 7(MAY). doi: 10.3389/fbioe.2019.129.

Kollech, H.G., Ayyalasomayajula, A., Behkam, R., Tamimi, E., Furdella, K., Drewry, M., & Vande Geest, J.P. (2019). A Subdomain Method for Mapping the Heterogeneous Mechanical Properties of the Human Posterior Sclera. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 7, 129.Frontiers Media SA. doi: 10.3389/fbioe.2019.00129.

Tamimi, E.A., Ardila, D.C., Ensley, B.D., Kellar, R.S., & Vande Geest, J. (2019). Computationally optimizing the compliance of multilayered biomimetic tissue engineered vascular grafts. J Biomech Eng, 141(6).ASME International. doi: 10.1115/1.4042902.

Ram, S., Danford, F., Howerton, S., Rodriguez, J.J., & Vande Geest, J.P. (2018). Three-Dimensional Segmentation of the Ex-Vivo Anterior Lamina Cribrosa From Second-Harmonic Imaging Microscopy. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 65(7), 1617-1629.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TBME.2017.2674521.

Behkam, R., Roberts, K.E., Bierhals, A.J., Jacobs, M.E., Edgar, J.D., Paniello, R.C., Woodson, G., Geest, J.P.V., & Barkmeier-Kraemer, J.M. (2017). Aortic arch compliance and idiopathic unilateral vocal fold paralysis. JOURNAL OF APPLIED PHYSIOLOGY, 123(2), 303-309.American Physiological Society. doi: 10.1152/japplphysiol.00239.2017.

Furdella, K.J., Witte, R.S., & Vande Geest, J.P. (2017). Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy. JOURNAL OF BIOMEDICAL OPTICS, 22(4), 41016.SPIE-Intl Soc Optical Eng. doi: 10.1117/1.JBO.22.4.041016.

Tamimi, E.A., Pyne, J.D., Muli, D.K., Axman, K.E., Howerton, S.J., Davis, M.R., Girkin, C.A., & Vande Geest, J.P. (2017). Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(10), 4235-4246.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.17-22141.

Armstrong, M.H., Tepole, A.B., Kuhl, E., Simon, B.R., & Vande Geest, J.P. (2016). A Finite Element Model for Mixed Porohyperelasticity with Transport, Swelling, and Growth. In Aliseda, A. (Ed.). PLOS ONE, 11(4), e0152806.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0152806.

Ayyalasomayajula, A., Park, R.I., Simon, B.R., & Vande Geest, J.P. (2016). A porohyperelastic finite element model of the eye: the influence of stiffness and permeability on intraocular pressure and optic nerve head biomechanics. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, 19(6), 591-602.Informa UK Limited. doi: 10.1080/10255842.2015.1052417.

Harrison, S., Tamimi, E., Uhlorn, J., Leach, T., & Vande Geest, J.P. (2016). Computationally Optimizing the Compliance of a Biopolymer Based Tissue Engineered Vascular Graft. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 138(1).ASME International. doi: 10.1115/1.4032060.

Haskett, D.G., Maestas, D., Howerton, S.J., Smith, T., Ardila, D.C., Doetschman, T., Utzinger, U., McGrath, D., McIntyre, J.O., & Vande Geest, J.P. (2016). 2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm. MICROSCOPY AND MICROANALYSIS, 22(2), 349-360.Cambridge University Press (CUP). doi: 10.1017/S1431927616000088.

Tamimi, E., Ardila, D.C., Haskett, D.G., Doetschman, T., Slepian, M.J., Kellar, R.S., & Vande Geest, J.P. (2016). Biomechanical Comparison of Glutaraldehyde-Crosslinked Gelatin Fibrinogen Electrospun Scaffolds to Porcine Coronary Arteries. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 138(1).ASME International. doi: 10.1115/1.4031847.

Ardila, D.C., Tamimi, E., Danford, F.L., Haskett, D.G., Kellar, R.S., Doetschman, T., & Vande Geest, J.P. (2015). TGF beta 2 differentially modulates smooth muscle cell proliferation and migration in electrospun gelatin-fibrinogen constructs. BIOMATERIALS, 37, 164-173.Elsevier BV. doi: 10.1016/j.biomaterials.2014.10.021.

Williams, M.J., Ayylasomayajula, A., Behkam, R., Bierhals, A.J., Jacobs, M.E., Edgar, J.D., Paniello, R.C., Barkmeier-Kraemer, J.M., & Geest, J.P.V. (2015). A computational study of the role of the aortic arch in idiopathic unilateral vocal-fold paralysis. JOURNAL OF APPLIED PHYSIOLOGY, 118(4), 465-474.American Physiological Society. doi: 10.1152/japplphysiol.00638.2014.

Harper, J.L., Simon, B.R., & Geest, J.P.V. (2014). A one-dimensional mixed porohyperelastic transport swelling finite element model with growth. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 29, 663-675.Elsevier BV. doi: 10.1016/j.jmbbm.2013.04.019.

Pyne, J.D., Genovese, K., Casaletto, L., & Vande Geest, J.P. (2014). Sequential-Digital Image Correlation for Mapping Human Posterior Sclera and Optic Nerve Head Deformation. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 136(2), 021002.ASME International. doi: 10.1115/1.4026224.

Williams, M.J., Utzinger, U., Barkmeier-Kraemer, J.M., & Vande Geest, J.P. (2014). Differences in the Microstructure and Biomechanical Properties of the Recurrent Laryngeal Nerve as a Function of Age and Location. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 136(8).ASME International. doi: 10.1115/1.4027682.

Danford, F.L., Yan, D., Dreier, R.A., Cahir, T.M., Girkin, C.A., & Vande Geest, J.P. (2013). Differences in the Region- and Depth-Dependent Microstructural Organization in Normal Versus Glaucomatous Human Posterior Sclerae. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(13), 7922-7932.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.13-12262.

Haskett, D., Azhar, M., Utzinger, U., & Vande Geest, J.P. (2013). Progressive alterations in microstructural organization and biomechanical response in the ApoE mouse model of aneurysm. Biomatter, 3(3).Informa UK Limited. doi: 10.4161/biom.24648.

Haskett, D., Johnson, G., Zhou, A., Utzinger, U., & Vande Geest, J. (2013). Erratum to: Microstructural and biomechanical alterations of the human aorta as a function of age and location (vol 12, pg 413, 2013). BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 12(2), 413-414.Springer Science and Business Media LLC. doi: 10.1007/s10237-012-0415-6.

Keyes, J.T., Lockwood, D.R., Simon, B.R., & Vande Geest, J.P. (2013). Deformationally dependent fluid transport properties of porcine coronary arteries based on location in the coronary vasculature. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 17, 296-306.Elsevier BV. doi: 10.1016/j.jmbbm.2012.10.002.

Keyes, J.T., Lockwood, D.R., Utzinger, U., Montilla, L.G., Witte, R.S., & Vande Geest, J.P. (2013). Comparisons of Planar and Tubular Biaxial Tensile Testing Protocols of the Same Porcine Coronary Arteries. ANNALS OF BIOMEDICAL ENGINEERING, 41(7), 1579-1591.Springer Science and Business Media LLC. doi: 10.1007/s10439-012-0679-0.

Keyes, J.T., Simon, B.R., & Geest, J.P.V. (2013). A Finite Element Study on Variations in Mass Transport in Stented Porcine Coronary Arteries Based on Location in the Coronary Arterial Tree. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(6), 61008-61011.ASME International. doi: 10.1115/1.4024137.

Keyes, J.T., Simon, B.R., & Vande Geest, J.P. (2013). Location-Dependent Coronary Artery Diffusive and Convective Mass Transport Properties of a Lipophilic Drug Surrogate Measured Using Nonlinear Microscopy. PHARMACEUTICAL RESEARCH, 30(4), 1147-1160.Springer Science and Business Media LLC. doi: 10.1007/s11095-012-0950-y.

Warren, P.D., Sycks, D.G., McGrath, D.V., & Vande Geest, J.P. (2013). Modeling the microstructurally dependent mechanical properties of poly(ester-urethane-urea)s. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 101(12), 3382-3387.Wiley. doi: 10.1002/jbm.a.34641.

Haskett, D., Doyle, J.J., Gard, C., Chen, H., Ball, C., Estabrook, M.A., Encinas, A.C., Dietz, H.C., Utzinger, U., Vande Geest, J.P., & Azhar, M. (2012). Altered tissue behavior of a non-aneurysmal descending thoracic aorta in the mouse model of Marfan syndrome. CELL AND TISSUE RESEARCH, 347(1), 267-277.Springer Science and Business Media LLC. doi: 10.1007/s00441-011-1270-y.

Haskett, D., Speicher, E., Fouts, M., Larson, D., Azhar, M., Utzinger, U., & Geest, J.V. (2012). The effects of angiotensin II on the coupled microstructural and biomechanical response of C57BL/6 mouse aorta. JOURNAL OF BIOMECHANICS, 45(5), 772-779.Elsevier BV. doi: 10.1016/j.jbiomech.2011.11.017.

Holmes, J.W., & Geest, J.P.V. (2012). Cardiovascular solid mechanics grows and remodels. JOURNAL OF BIOMECHANICS, 45(5), 727.Elsevier BV. doi: 10.1016/j.jbiomech.2011.11.011.

Ashton, J.H., Ayyalasomayajula, A., Simon, B.R., & Geest, J.P.V. (2011). Wall Stress Reduction in Abdominal Aortic Aneurysms as a Result of Polymeric Endoaortic Paving. ANNALS OF BIOMEDICAL ENGINEERING, 39(6), 1680-1689.Springer Science and Business Media LLC. doi: 10.1007/s10439-011-0271-z.


Research Interests



Graduate Program

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