Tolani Olonisakin, PhD

Education & Training

  • Fisk University, BA, 2012
  • University of Pittsburgh, PhD, 2020

Representative Publications

Bain W, Li H, van der Geest R, Moore SR, Olonisakin TF, Ahn B, Papke E, Moghbeli K, DeSensi R, Rapport S, Saul M, Hulver M, Xiong Z, Mallampalli RK, Ray P, Morris A, Ma L, Doi Y, Zhang Y, Kitsios GD, Kulkarni HS, McVerry BJ, Ferreira VP, Nouraie M, Lee JS. Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness. Am J Respir Crit Care Med. 2020;202(2):230-40. Epub 2020/05/07. doi: 10.1164/rccm.201910-2083OC. PubMed PMID: 32374177; PMCID: PMC7365364.

Bain W, Olonisakin T, Yu M, Qu Y, Hulver M, Xiong Z, Li H, Pilewski J, Mallampalli RK, Nouraie M, Ray A, Ray P, Cheng Z, Shanks RMQ, St Croix C, Silverstein RL, Lee JS. Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury. Blood Adv. 2019;3(3):432-45. Epub 2019/02/09. doi: 10.1182/bloodadvances.2018026286. PubMed PMID: 30733303; PMCID: PMC6373758.

Han S, Olonisakin TF, Pribis JP, Zupetic J, Yoon JH, Holleran KM, Jeong K, Shaikh N, Rubio DM, Lee JS. A checklist is associated with increased quality of reporting preclinical biomedical research: A systematic review. PLoS One. 2017;12(9):e0183591. Epub 2017/09/14. doi: 10.1371/journal.pone.0183591. PubMed PMID: 28902887; PMCID: PMC5597130.

Olonisakin TF, Lee JS. Fighting Bacterial Pathogens in the Lung: Platelets to the Rescue? Am J Respir Cell Mol Biol. 2018;58(3):282-3. Epub 2018/03/02. doi: 10.1165/rcmb.2017-0349ED. PubMed PMID: 29493323; PMCID: PMC5854961.

Olonisakin TF, Li H, Xiong Z, Kochman EJ, Yu M, Qu Y, Hulver M, Kolls JK, St Croix C, Doi Y, Nguyen MH, Shanks RM, Mallampalli RK, Kagan VE, Ray A, Silverstein RL, Ray P, Lee JS. CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis. J Infect Dis. 2016;214(12):1865-75. Epub 2016/09/30. doi: 10.1093/infdis/jiw451. PubMed PMID: 27683817; PMCID: PMC5142085.

Olonisakin TF, Suber T, Gonzalez-Ferrer S, Xiong Z, Penaloza HF, van der Geest R, Xiong Y, Osei-Hwedieh DO, Tejero J, Rosengart MR, Mars WM, Van Tyne D, Perlegas A, Brashears S, Kim-Shapiro DB, Gladwin MT, Bachman MA, Hod EA, St Croix C, Tyurina YY, Kagan VE, Mallampalli RK, Ray A, Ray P, Lee JS. Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation. J Clin Invest. 2021;131(1). Epub 2020/09/18. doi: 10.1172/JCI137468. PubMed PMID: 32941182; PMCID: PMC7773401.

Qu Y, Olonisakin T, Bain W, Zupetic J, Brown R, Hulver M, Xiong Z, Tejero J, Shanks RM, Bomberger JM, Cooper VS, Zegans ME, Ryu H, Han J, Pilewski J, Ray A, Cheng Z, Ray P, Lee JS. Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis. JCI Insight. 2018;3(3). Epub 2018/02/09. doi: 10.1172/jci.insight.96914. PubMed PMID: 29415890; PMCID: PMC5821195.

Zhao Y, Olonisakin TF, Xiong Z, Hulver M, Sayeed S, Yu MT, Gregory AD, Kochman EJ, Chen BB, Mallampalli RK, Sun M, Silverstein RL, Stolz DB, Shapiro SD, Ray A, Ray P, Lee JS. Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection. Mucosal Immunol. 2015;8(4):896-905. Epub 2014/12/11. doi: 10.1038/mi.2014.120. PubMed PMID: 25492474; PMCID: PMC4465063.

Student Year

MS4

Career Advisor

Sally Wenzel, MD

Thesis Advisor

Janet Lee, MD

Graduate Program

Dissertation Title

Stressed Erythrophagocytosis as a modifier of the innate immune response to klebsiella pneumoniae

Trainee

Current

Training Period

2013-present

Student Year Term

MS4