Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors by Laura Molina

Molina et al. demonstrate that loss of Yap1 in developing livers leads to absence of intrahepatic bile ducts, preventing bile secretion from liver to small intestines. Yap1 knockout mice are small and jaundiced and exhibit adaptation via altering bile acid transport and metabolism, but they eventually die around 8 months of age.

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