Vascularized composite allotransplantation (VCA) is an emerging field that is particularly beneficial for select amputees and patients with devastating soft tissue loss that is not amenable to conventional reconstructive surgeries. As with solid o...
News Archive
Post Date:
11-19-2019
From the article in Cell Reports: Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacter...
Post Date:
09-10-2019
From the article in Blood Advances: Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single point mutation in the β-globin gene. As a consequence, deoxygenated hemoglobin po...
Post Date:
08-02-2019
From the article in Journal of Cardiac Surgery: A 46‐year‐old female presented with native tricuspid valve endocarditis complicated by a stroke with a hemorrhagic component. There was no evidence...
Post Date:
08-01-2019
From the article in Experimental Cell Research: The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a w...
Post Date:
07-23-2019
From the article in Biochemistry: Cytoglobin is a heme protein evolutionarily related to hemoglobin and myoglobin. Cytoglobin is expressed ubiquitously in mammalian tissues; however, its physiological functions are yet unclear. Phylogenetic analys...
Post Date:
07-19-2019
From the article in Cell: Cutaneous TRPV1+ neurons directly sense noxious stimuli, inflammatory cytokines, and pathogen-associated molecules and are required for innate immunity against some skin pathogens. Important unanswered questions are...
Post Date:
07-08-2019
From the article in JAMA Internal Medicine: Based on the outcomes of this model, adoption of a 12-month dispensing option for oral contraceptive pills may support reproductive autonomy and improve reproductive outcomes among women veterans and is...
Post Date:
07-08-2019
From the article in Schizophrenia Research: Cognitive dysfunction in individuals with schizophrenia is thought to reflect, at least in part, altered levels of excitatory and inhibitory neurotransmission in the dorsolateral prefrontal cortex (DLPFC...
Post Date:
07-03-2019
Background
The aim of this study was to identify hospital‐level predictors of increased cost following index adult cardiac operations in a statewide registry.
Methods
The Pennsylvania Healt...
Post Date:
06-27-2019
From the article: Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that requires novel therapies in the advanced setting. To study acquired resistance to endocrine therapy in ILC, we have recently performed RNA-Sequenci...
Post Date:
06-18-2019
From the article: Spontaneous rupture of the left subclavian artery is a rare condition that requires immediate surgical intervention. A 21‐year‐old man with a history of membranoproliferative glomerulonephritis, failed kidney transplant, and hist...
Post Date:
05-01-2019
Transcatheter aortic valve replacement (TAVR) is an area of rapid advancement in cardiac surgery. Through subsequent randomized controlled trials, its indications have broadened and its use steadily increased (1,2). However, risk assessment for TA...
Post Date:
03-18-2019
From the article: Although shape perception is primarily considered a function of the ventral visual pathway, previous research has shown that both dorsal and ventral pathways represent shape information. Here, we examine whether the shape-selecti...
Post Date:
03-15-2019
In the article: Schimmelpenning syndrome is a rare, well-defined constellation of clinical phenotypes associated with the presence of nevus sebaceous and multisystem abnormalities most commonly manifested as cerebral, ocular, and skeletal defects....
Post Date:
02-19-2019
mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development by Laura Molina
From the article: Hepatoblastoma (HB) is the most common pediatric liver malignancy. Around 80% of HB demonstrate simultaneous activation of β-catenin and Yes-associated protein 1 (Yap1). The mechanism by which these signaling pathways contribute...
Post Date:
02-13-2019
From the article: Bipolar disorder (BD) is a serious psychiatric illness with demonstrated abnormalities in reward processing circuitry. Examining this circuitry in youth at familial risk for BD may provide further insight into the underlying mech...
Post Date:
01-22-2019
From the article: A long-standing goal in neuroscience has been to bring together neuronal recordings and neural network modeling to understand brain function. Neuronal recordings can inform the development of network models, and network models ca...
Post Date:
01-15-2019
Background
Early detection of Bipolar Disorder (BD) is critical for targeting interventions to delay or prevent illness onset. Yet, the absence of objective BD biomarkers makes accurately identifying at-risk youth difficul...
Post Date:
12-01-2018
Background:
There is extensive debate on the role of fixed pressure shunts in the adult population. Most studies assessing fixed pressure valves do not consider the potential for changes in technique and management of shun...
Post Date:
11-22-2018
From the article: Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species. Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and is maint...
Post Date:
11-20-2018
From the article: Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for the treatment of high cholesterol and atheroscler...
Post Date:
10-01-2018
BACKGROUND:
Metastasis in breast cancer foreshadows mortality, as clinically evident disease is aggressive and generally chemoresistant. Disseminated breast cancer cells often enter a period of dormancy for years to decade...
Post Date:
09-02-2018
From the article: Our appreciation of the roles of non-coding RNAs, in particular microRNAs, in the manifestation of pulmonary hypertension (PH) has advanced considerably over the past decade. Comprised of small nucleotide sequences, microRNAs hav...
Post Date:
08-31-2018
From the article: Pulmonary hypertension (PH) is a heterogeneous and fatal disease of the lung vasculature, where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the Warburg effect in cancer, a shift from mitochondrial o...
Post Date:
08-31-2018
From the article: Patients with EGFR-mutant non-small-cell lung cancer (NSCLC) have significantly benefited from the use of EGFR tyrosine kinase inhibitors (TKIs). However, long-term efficacy of these therapies is limited due to de novo resistance...
Post Date:
07-30-2018
From the article: Mitochondria are a keystone of neuronal function, serving a dual role as sustainer of life and harbinger of death. While mitochondria are indispensable for energy production, a dysregulated mitochondrial network can spell doom fo...
Post Date:
06-30-2018
From the article: Humans recognize faces with ease, despite the complexity of the task and of the visual system which underlies it. Different spatial regions, including both the core and extended face processing networks, and distinct temporal sta...
Post Date:
06-22-2018
From the article: Certain clinical features of schizophrenia, such as working memory disturbances, appear to emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the essential role of GABA neurotransmission in both...
Post Date:
04-27-2018
From the article: Cell‐lineage tracing is used to study embryo development and stem‐cell differentiation as well as to document tumor cell heterogeneity. Cre recombinase‐mediated cell labeling is the preferred approach; however, its utility is res...
Post Date:
03-01-2018
From the article: Pseudomonas aeruginosa is an extracellular Gram-negative, bacterial, opportunistic pathogen that exploits immunocompromised hosts. Although it is notorious for its ability to persist in the cystic fibrosis lung and establish chro...