News
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and whether scratching provides benefit to the host are...
Nathalie Chen earns the prestigious American Heart Association Predoctoral Fellowship. Congratulations, Nathalie!
Female individuals who are post-menopausal present with higher incidence of knee osteoarthritis (KOA) than male counterparts; however, the mechanisms underlying this disparity are unknown. The most commonly used preclinical models lack human...
Background: Pulmonary arterial hypertension (PAH) is a deadly disease without effective non-invasive diagnostic and prognostic testing. It remains unclear whether vasodila...
Background: People with Alzheimer's disease (AD) exhibit varying clinical trajectories. There is a need to predict future AD-related outcomes such as morbidity and mortali...
First-line immune checkpoint inhibitor (ICI) combinations show responses in subsets of hepatocellular carcinoma (HCC) patients. Nearly half of HCCs are Wnt-active with mutations in CTNNB1 (encoding for β-catenin), AXIN1/2, or...
Transcriptomic analyses have advanced the understanding of complex disease pathophysiology including chronic obstructive pulmonary disease (COPD). However, identifying relevant biologic causative factors has been limited by the integration of high...
Resting heart rate may confer risk for cardiovascular disease (CVD) and other adverse cardiovascular events. While the brainstem's autonomic control over heart rate is well established, less is known about the regulatory role of higher level corti...
Importance: Choosing Wisely recommendations advocate against routine use of axillary staging in older women with early-stage, clinically node-negative (cN0), hormone receptor-positive (HR+), and HER2-negative breast cancer. Howev...
Immunosenescence is a well-characterized phenomenon that occurs with increasing age in all immune and somatic cells. In order to best study immunosenescence, it is imperative to develop methods to accurately identify immunosenescent cells. Elderly...
Alzheimer's disease (AD) and more than twenty other dementias, termed tauopathies, are pathologically defined by insoluble aggregates of the microtubule-associated protein tau (MAPT). Although tau aggregation correlates with AD symptomology, the s...
Alzheimer disease (AD) and obesity are related to disruptions in the white matter (WM) connectome. We examined the link between the WM connectome and obesity and AD through edge-density imaging/index (EDI), a tractography-based method that charact...
Traumatic brain injury (TBI) remains a leading cause of death and disability that places a great physical, social, and financial burden on individuals and the health system. In this review, we summarize new research into the metabolic changes desc...
Permanent supportive housing (PSH) programs, which have grown over the last decade, have been associated with changes in health care utilization and spending. However, little is known about the impact of such programs on use of prescription drugs...
Copper is a critical trace element in biological systems due the vast number of essential enzymes that require the metal as a cofactor, including cytochrome c oxidase, superoxide dismutase and dopamine-β-hydroxylase. Due its key role in oxidative...
Precision management of fibrotic lung diseases is challenging due to their diverse clinical trajectories and lack of reliable biomarkers for risk stratification and therapeutic monitoring. Here, we validated the accuracy of CMKLR1 as an imaging bi...
The fundamental steps in high-grade serous ovarian cancer (HGSOC) initiation are unclear, thus providing critical barriers to the development of prevention or early detection strategies for this deadly disease. Increasing evidence demonstrates mos...
Matthew Eric Piraino Awards for Excellence in Infectious Disease
This award is to be given to a fourth-year medical student with an interest in infectious diseases. This year’s award is presented to Alexander Layden
Frank...
Purpose: Natural language understanding (NLU) may be particularly well equipped for enhanced data capture from the electronic health record given its examination of both c...
The role of neurogenesis in neurodevelopmental disorders (NDDs) merits much attention. The complex process by which stem cells produce daughter cells that in turn differentiate into neurons, migrate various distances, and form synaptic connections...
Background: Although cardiac rehabilitation (CR) has established benefits for cardiovascular health, it remains significantly underutilized, with substantial differences i...
Congratulations to Gabby Gilmer on achieving 3rd place in the Poster Presentation at AR3T-Alliance for Regenerative Rehabilitation Research & Training!...
Dr. Mehret Birru Talabi from @PittRheum...
Background: The coronavirus disease 2019 (COVID-19) pandemic has negatively affected the social fabric.
Objective: We evaluated the associations...
Anna Kirillova wins the prestigious Rupert Swift Award at the Pulmonary Vascular Research Institute annual meeting in London, England.
In brain, the striatum is a heterogenous region involved in reward and goal-directed behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use disorder (OUD). Striatal subregions are divided based on neuroanatomy, ea...
Most women ≥70 years undergo breast surgery for primary treatment of estrogen receptor (ER) positive breast cancer. Only a small minority forego surgical intervention despite a growing body of literature, mainly from the United Kingdom (UK) and Th...
The nature and extent of hemispheric lateralization and its potential for reorganization continues to be debated, although there is general agreement that there is a right hemisphere (RH) advantage for face processing in human adults. Here, we exa...
The Pennsylvania Rural Health Model (PARHM) is a novel alternative payment model for rural hospitals that aims to test whether hospital-based global budgets, coupled with delivery transformation plans, improve the quality of health care and health...
Many important neurocognitive states, such as performing natural activities and fluctuations of arousal, shift over minutes-to-hours in the real-world. We harnessed 3-12 days of continuous multi-electrode intracranial recordings in twenty humans d...
Resting heart rate may confer risk for cardiovascular disease (CVD) and other adverse cardiovascular events. While the brainstem's autonomic control over heart rate is well established, less is known about the regulatory role of higher-level corti...
Congratulations to Gabby Gilmer, G3, for winning the Mininder S. Kocher Award for Most Promising Career from the Pediatric Research in Sports Medicine group
A collaborative group of neuroscientists from Carnegie Mellon University and the University of Pittsburgh School of Medicine received a $6.8 million grant from the National Institutes of Health (NIH) Brain Research Through Advancing Innovative Neu...
Tissue engineering utilizes our understanding of biomechanics, biomaterials, and biology to build tissues and organs from scratch for diagnostics and therapeutics. This approach has been leveled at clinical and research problems in all organ syste...
Please join Pitt/CMU MSTP for Edgar's Thesis Defense titled "Towards patient specific direct cardiac compression" on June 28th at 1pm.
Join Zoom Meeting https://cmu.zoom.us/j/99613388722?pwd=U0RWZWJ1bU5sRDh1Yk95bENRcytqUT09
Meeting...
Abstract
Objectives:
Initial evidence suggests that state-level regulatory mandates for sepsis quality improvement are associated with decreased sepsis mortality. However, sepsis mandates require financial investments on the p...
PITTSBURGH— Martial Hebert, dean of Carnegie Mellon University’s School of Computer Science, has named Russell Schwartz the new head of the Computational Biology Department, effective July 1.
Schwartz, a professor in both the Computational...
From the Article In Cell Press: The lateral parabrachial nucleus (lPBN) is a majortarget of spinal projection neurons conveying noci-ceptive input into supraspinal structures. However,the functional role of distinct lPBN efferents indiverse nocife...
From the article in Pediatric Transplant: The high discard rate of pediatric donor hearts presents a major challenge for children awaiting heart transplantation. Recent literature identifies several factors that contribute to the disparities in pe...
Maxwell Wang was selected for one of the most prestigious awards of its kind, the Hertz Fellowship. This Fellowship supports five years of graduate research and the freedom to pursue innovative ideas, wherever they may lead. Hertz Fellows also rec...
From the article in The Journal of Neuroscience: Autism spectrum disorder (ASD) is characterized partly by atypical attentional engagement, reflected in exaggerated and variable responses to sensory stimuli. Attentional engagement is known to be r...
From the article in Journal of Neurophysiology: Separating neural signals from noise can improve brain-computer interface performance and stability. However, most algorithms for separating neural action potentials from noise are not suitable for u...
From the article in Chemical Communications: Site-specific placement of unnatural amino acids, particularly those responsive to light, offers an elegant approach to control protein function and capture their fleeting ‘interactome’. Herein, we have...
Increasing evidence implicates metabolic pathways as key regulators of cell fate and function. Although the metabolism of glucose, amino acids, and fatty acids is essential to maintain over...