- University of Pittsburgh, PhD, 2024
- Carroll College, BA, 2012
Education & Training
Representative Publications
Mann JR, Gleixner AM, Gomes E, DeChellis-Marks MR, Needham PG, Hurtle B, Portz B, Mauna JC, Calder CB, Copley KE, Wills ZP, Pandey UB, Brodsky JL, Thathiah A, Shorter J, Donnelly, CJ. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. (2019) Neuron. 102:321-338.
Huang Y, Rafael Guimarães T, Todd N, Ferguson C, Weiss KM, Stauffer FR, McDermott B, Hurtle BT, Saito T, Saido TC, MacDonald ML, Homanics GE, Thathiah A. G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2204828119. doi: 10.1073/pnas.2204828119. Epub 2022 Sep 26. PMID: 36161942; PMCID: PMC9546571.
Hurtle BT, Xie L, Donnelly CJ. Disrupting pathologic phase transitions in neurodegeneration. J Clin Invest. 2023 Jul 3;133(13):e168549. doi: 10.1172/JCI168549. PMID: 37395272; PMCID: PMC10313377.
Hurtle B, Donnelly CJ, Zhang X, Thathiah A. Live-cell visualization of tau aggregation in human neurons. Commun Biol. 2024 Sep 14;7(1):1143. doi: 10.1038/s42003-024-06840-z. PMID: 39277689; PMCID: PMC11401922.
Xie L, Merjane J, Bergmann CA, Xu J, Hurtle B, Donnelly CJ. CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function. bioRxiv [Preprint]. 2024 Jul 12:2024.07.12.603231. doi: 10.1101/2024.07.12.603231. PMID: 39026766; PMCID: PMC11257528.
Research Interests
Abnormal Tau Interactions in Neurodegenerative Disease
Student Year
MS3
Career Advisor
Clayton Wiley, MD, PhD
Thesis Advisor
Christopher J Donnelly, PhD
Program
Neuroscience (CNUP)
Dissertation Title
Abnormal Tau Interactions in Neurodegenerative Disease
Trainee
Current
Training Start Year
2016