- Carnegie Mellon University, BS, 2018
Education & Training
Bleimeister IH, Avni I, Granovetter MC, Meiri G, Ilan M, Michaelovski A, Menashe I, Behrmann M, Dinstein I. Idiosyncratic pupil regulation in autistic children. Autism Res. 2024 Dec;17(12):2503-2513. doi: 10.1002/aur.3234. Epub 2024 Oct 10. PMID: 39385709; PMCID: PMC11638892.
Chen H, Bleimeister IH, Nguyen EK, Li J, Cui AY, Stratton HJ, Smith KM, Baccei ML, Ross SE. The functional and anatomical characterization of three spinal output pathways of the anterolateral tract. Cell Rep. 2024 Mar 26;43(3):113829. doi: 10.1016/j.celrep.2024.113829. Epub 2024 Feb 28. PMID: 38421871; PMCID: PMC11025583.
Bleimeister I, Avni I, Granovetter M, Meiri G, Ilan M, Michaelovski A, Menashe I, Behrmann M, Dinstein I. Idiosyncratic pupil regulation in autistic children. bioRxiv [Preprint]. 2024 Jan 12:2024.01.10.575072. doi: 10.1101/2024.01.10.575072. Update in: Autism Res. 2024 Dec;17(12):2503-2513. doi: 10.1002/aur.3234. PMID: 38260528; PMCID: PMC10802609.
Nguyen E, Smith KM, Cramer N, Holland RA, Bleimeister IH, Flores-Felix K, Silberberg H, Keller A, Le Pichon CE, Ross SE. Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit. Brain. 2022 Jul 29;145(7):2586-2601. doi: 10.1093/brain/awac189. PMID: 35598161; PMCID: PMC9612802.
Under acutely stressful conditions, the brain is able to alter a person's perception of pain to facilitate their escape from dangerous, pain-inducing environments. Despite the prevalence of pain and the apparent importance of this phenomenon in promoting survival, the neurobiological mechanisms underlying this effect are not fully understood. Using preclinical models to assess the role of distinct neuronal populations in driving this effect, I am working towards further characterizing the degree to which this descending modulatory circuit is capable of suppressing the ascending nociceptive signal at the level of the spinal cord, during acute stress.