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Jenna Gale PhD

    Education & Training

  • Vassar College, B.A., 2011
  • University of Pittsburgh, PhD, 2023
Representative Publications

Gale J, Aizenman E. The physiological and pathophysiological roles of copper in the nervous system. Eur J Neurosci. 2024 Jul;60(1):3505-3543. doi: 10.1111/ejn.16370. Epub 2024 May 15. PMID: 38747014.

Gale, J. R., Hartnett-Scott, K., Ross, M. M., Rosenberg, P. A., & Aizenman, E. (2023). Copper induces neuron-sparing, ferredoxin 1-independent astrocyte toxicity mediated by oxidative stress. Journal of neurochemistry, 10.1111/jnc.15961. Advance online publication. https://doi.org/10.1111/jnc.15961

Hernandez-Espinosa, D. R., Gale, J. R., Scrabis, M. G., & Aizenman, E. (2023). Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity. Journal of neurochemistry, 165(1), 29–54. https://doi.org/10.1111/jnc.15760

Krall, R., Gale, J. R., Ross, M. M., Tzounopoulos, T., & Aizenman, E. (2022). Intracellular zinc signaling influences NMDA receptor function by enhancing the interaction of ZnT1 with GluN2A. Neuroscience letters, 790, 136896. https://doi.org/10.1016/j.neulet.2022.136896

Gleixner, A. M., Verdone, B. M., Otte, C. G., Anderson, E. N., Ramesh, N., Shapiro, O. R., Gale, J. R., Mauna, J. C., Mann, J. R., Copley, K. E., Daley, E. L., Ortega, J. A., Cicardi, M. E., Kiskinis, E., Kofler, J., Pandey, U. B., Trotti, D., & Donnelly, C. J. (2022). NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility. Nature communications, 13(1), 3380. https://doi.org/10.1038/s41467-022-31098-6

Gale, J. R., Gedeon, J. Y., Donnelly, C. J., & Gold, M. S. (2022). Local translation in primary afferents and its contribution to pain. Pain, 163(12), 2302–2314. https://doi.org/10.1097/j.pain.0000000000002658

Gale, J. R., Kosobucki, G. J., Hartnett-Scott, K. A., & Aizenman, E. (2021). Imprecision in Precision Medicine: Differential Response of a Disease-Linked GluN2A Mutant to NMDA Channel Blockers. Frontiers in pharmacology, 12, 773455. https://doi.org/10.3389/fphar.2021.773455

Liu, H. Y., Gale, J. R., Reynolds, I. J., Weiss, J. H., & Aizenman, E. (2021). The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction. Biomedicines, 9(5), 489. https://doi.org/10.3390/biomedicines9050489

Snyder LM, Chiang MC, Loeza-Alcocer E, Omori Y, Hachisuka J, Sheahan TD, Gale JR, Adelman PC, Sypek EI, Fulton SA, Friedman RL, Wright MC, Duque MG, Lee YS, Hu Z, Huang H, Cai X, Meerschaert KA, Nagarajan V, Hirai T, Scherrer G, Kaplan DH, Porreca F, Davis BM, Gold MS, Koerber HR, Ross SE. Kappa Opioid Receptor Distribution and Function in Primary Afferents. Neuron. 2018 Sep 19;99(6):1274-1288.e6. doi: 10.1016/j.neuron.2018.08.044. PMID: 30236284; PMCID: PMC6300132.
Student Year
MS4
Career Advisor
Sarah Berman, MD, PhD
Thesis Advisor
Elias Aizenman, PhD
Program
Neuroscience (CNUP)
Dissertation Title

Insights into the mechanism of copper-ionophore mediated toxicity in glial cells.

Trainee
Current
Training Start Year
2017