Publications

Trainee: Current

Faculty Member: David Lewis, MD

Publications:

Dienel SJ, Bazmi HH, Lewis DA. Development of transcripts regulating dendritic spines in layer 3 pyramidal cells of the monkey prefrontal cortex: Implications for the pathogenesis of schizophrenia. Neurobiol Dis. 2017 Sep;105:132-141. doi: 10.1016/j.nbd.2017.05.016. Epub 2017 May 31.

Hoftman GD, Dienel SJ, Bazmi HH, Zhang Y, Chen K, Lewis DA. Altered Gradients of Glutamate and Gamma-Aminobutyric Acid Transcripts in the Cortical Visuospatial Working Memory Network in Schizophrenia. Biol Psychiatry. 2018 Apr 15;83(8):670-679. doi: 10.1016/j.biopsych.2017.11.029. Epub 2017 Dec 7.

Dienel SJ, Lewis DA. Alterations in cortical interneurons and cognitive function in schizophrenia. Neurobiol Dis. 2019 Nov;131:104208. doi: 10.1016/j.nbd.2018.06.020. Epub 2018 Jun 22.

Dienel SJ, Enwright JF 3rd, Hoftman GD, Lewis DA. Markers of glutamate and GABA neurotransmission in the prefrontal cortex of schizophrenia subjects: Disease effects differ across anatomical levels of resolution. Schizophr Res. 2020 Mar;217:86-94. doi: 10.1016/j.schres.2019.06.003. Epub 2019 Jul 8.

Schoonover KE, Dienel SJ, Lewis DA. Prefrontal cortical alterations of glutamate and GABA neurotransmission in schizophrenia: Insights for rational biomarker development. Biomark Neuropsychiatry. 2020 Dec;3:100015. doi: 10.1016/j.bionps.2020.100015. Epub 2020 May 18.

Trainee Name: Kevin Dowling

Trainee: Current

Faculty Member: David A Lewis, MD

Publications:

Dienel SJ, Dowling KF, Barile Z, Bazmi HH, Liu A, Vespoli JC, Fish KN, Lewis DA. Diagnostic Specificity and Association With Cognition of Molecular Alterations in Prefrontal Somatostatin Neurons in Schizophrenia. JAMA Psychiatry. 2023 Dec 1;80(12):1235-1245. doi: 10.1001/jamapsychiatry.2023.2972. PMID: 37647039; PMCID: PMC10469307.

Dowling KF, Dienel SJ, Barile Z, Bazmi HH, Lewis DA. Localization and Diagnostic Specificity of Glutamic Acid Decarboxylase Transcript Alterations in the Dorsolateral Prefrontal Cortex in Schizophrenia. Biol Psychiatry. 2023 Aug 15;94(4):322-331. doi: 10.1016/j.biopsych.2023.04.003. Epub 2023 Apr 14. PMID: 37061080; PMCID: PMC10524522.

Trainee Name: Erica Fan

Trainee: Current

Faculty Member: Andrea Rosso, PhD, MPH

Publications:

Fan EKY, Fan J. Regulation of alveolar macrophage death in acute lung inflammation. Respir Res. 2018 Mar 27;19(1):50. doi: 10.1186/s12931-018-0756-5. PMID: 29587748; PMCID: PMC5872399.

Zhou H, Fan EK, Fan J. Cell-Cell Interaction Mechanisms in Acute Lung Injury. Shock. 2021 Feb 1;55(2):167-176. doi: 10.1097/SHK.0000000000001598. PMID: 32694389; PMCID: PMC8185986.

Shaaban CE, Fan E, Klatt BN, Cohen AD, Snitz BE, Yu Z, Lopresti BJ, Villemagne VL, Klunk WE, Aizenstein HJ, Rosso AL. Brain health correlates of mobility-related confidence. Exp Gerontol. 2022 Jun 15;163:111776. doi: 10.1016/j.exger.2022.111776. Epub 2022 Mar 24. PMID: 35339632; PMCID: PMC9109136.

Wang J, Luan Y, Fan EK, Scott MJ, Li Y, Billiar TR, Wilson MA, Jiang Y, Fan J. TBK1/IKKε Negatively Regulate LPS-Induced Neutrophil Necroptosis and Lung Inflammation. Shock. 2021 Mar 1;55(3):338-348. doi: 10.1097/SHK.0000000000001632. PMID: 32925605; PMCID: PMC8183424.

Xu F, Zhang C, Zou Z, Fan EKY, Chen L, Li Y, Billiar TR, Wilson MA, Shi X, Fan J. Aging-related Atg5 defect impairs neutrophil extracellular traps formation. Immunology. 2017 Aug;151(4):417-432. doi: 10.1111/imm.12740. Epub 2017 May 16. PMID: 28375544; PMCID: PMC5506403.

Jiao Y, Li Z, Loughran PA, Fan EK, Scott MJ, Li Y, Billiar TR, Wilson MA, Shi X, Fan J. Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock. J Leukoc Biol. 2018 Feb;103(2):175-183. doi: 10.1189/jlb.3HI0517-173R. Epub 2017 Dec 28. PMID: 28801344; PMCID: PMC6346432.

Fan L, Sweet DR, Fan EK, Prosdocimo DA, Madera A, Jiang Z, Padmanabhan R, Haldar SM, Vinayachandran V, Jain MK. Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle. J Biol Chem. 2022 Jun;298(6):101926. doi: 10.1016/j.jbc.2022.101926. Epub 2022 Apr 9. PMID: 35413288; PMCID: PMC9190004.

Lai D, Tang J, Chen L, Fan EK, Scott MJ, Li Y, Billiar TR, Wilson MA, Fang X, Shu Q, Fan J. Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis. Cell Death Dis. 2018 Mar 6;9(3):369. doi: 10.1038/s41419-018-0412-5. PMID: 29511181; PMCID: PMC5840374.

Tang J, Zhou B, Scott MJ, Chen L, Lai D, Fan EK, Li Y, Wu Q, Billiar TR, Wilson MA, Wang P, Fan J. EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation. Protein Cell. 2020 Feb;11(2):144-149. doi: 10.1007/s13238-019-00668-8. Erratum in: Protein Cell. 2020 Aug;11(8):618-619. doi: 10.1007/s13238-019-00679-5. Erratum in: Protein Cell. 2024 Feb 23:pwae002. doi: 10.1093/procel/pwae002. PMID: 31705388; PMCID: PMC6954894.

Li Z, Jiao Y, Fan EK, Scott MJ, Li Y, Li S, Billiar TR, Wilson MA, Shi X, Fan J. Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria. J Immunol. 2017 Nov 1;199(9):3176-3186. doi: 10.4049/jimmunol.1700140. Epub 2017 Sep 25. PMID: 28947541; PMCID: PMC5679440.

He X, Qian Y, Li Z, Fan EK, Li Y, Wu L, Billiar TR, Wilson MA, Shi X, Fan J. TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism. Sci Rep. 2016 Aug 16;6:31663. doi: 10.1038/srep31663. PMID: 27526865; PMCID: PMC4985817.

Li Z, Fan EK, Liu J, Scott MJ, Li Y, Li S, Xie W, Billiar TR, Wilson MA, Jiang Y, Wang P, Fan J. Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma. Cell Death Dis. 2017 May 11;8(5):e2775. doi: 10.1038/cddis.2017.187. PMID: 28492546; PMCID: PMC5584526.

Tang J, Zhou B, Scott MJ, Chen L, Lai D, Fan EK, Li Y, Wu Q, Billiar TR, Wilson MA, Wang P, Fan J. Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation. Protein Cell. 2020 Aug;11(8):618-619. doi: 10.1007/s13238-019-00679-5. Erratum for: Protein Cell. 2020 Feb;11(2):144-149. doi: 10.1007/s13238-019-00668-8. PMID: 32125673; PMCID: PMC7381517.

Murali A, Sojati J, Levochkina M, Pressimone C, Griffith K, Fan E, Dakroub A. A Cross-Sectional Analysis of Community Perceptions of Flu and COVID-19 Vaccines at Turtle Creek Primary Care Center. Community Health Equity Res Policy. 2024 Jul;44(4):439-451. doi: 10.1177/2752535X231205665. Epub 2023 Oct 14. PMID: 37837451.

Trainee Name: Noah Freedman

Trainee: Current

Faculty Member: Aaron Batista, PhD

Publications:

Taylor IM, Patel NA, Freedman NC, Castagnola E, Cui XT. Direct in Vivo Electrochemical Detection of Resting Dopamine Using Poly(3,4-ethylenedioxythiophene)/Carbon Nanotube Functionalized Microelectrodes. Anal Chem. 2019 Oct 15;91(20):12917-12927. doi: 10.1021/acs.analchem.9b02904. Epub 2019 Sep 26. PMID: 31512849; PMCID: PMC7175412.

Trainee Name: George Gabriel MD, PhD

Trainee: Current

Faculty Member: Cecilia Lo, PhD

Publications:

Gabriel GC, Pazour GJ, Lo CW. Congenital Heart Defects and Ciliopathies Associated With Renal Phenotypes. Front Pediatr. 2018 Jun 15;6:175. doi: 10.3389/fped.2018.00175. eCollection 2018.

Gabriel GC, Young CB, Lo CW. Role of cilia in the pathogenesis of congenital heart disease. Semin Cell Dev Biol. 2020 May 14:S1084-9521(19)30166-1. doi: 10.1016/j.semcdb.2020.04.017. Online ahead of print.

Gabriel GC, Lo CW. Left-right patterning in congenital heart disease beyond heterotaxy. Am J Med Genet C Semin Med Genet. 2020 Mar;184(1):90-96. doi: 10.1002/ajmg.c.31768. Epub 2020 Jan 30.

Trainee Name: Jenna Gale PhD

Trainee: Current

Faculty Member: Elias Aizenman, PhD

Publications:

Gale J, Aizenman E. The physiological and pathophysiological roles of copper in the nervous system. Eur J Neurosci. 2024 Jul;60(1):3505-3543. doi: 10.1111/ejn.16370. Epub 2024 May 15. PMID: 38747014.

Gale, J. R., Hartnett-Scott, K., Ross, M. M., Rosenberg, P. A., & Aizenman, E. (2023). Copper induces neuron-sparing, ferredoxin 1-independent astrocyte toxicity mediated by oxidative stress. Journal of neurochemistry, 10.1111/jnc.15961. Advance online publication. https://doi.org/10.1111/jnc.15961

Hernandez-Espinosa, D. R., Gale, J. R., Scrabis, M. G., & Aizenman, E. (2023). Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity. Journal of neurochemistry, 165(1), 29–54. https://doi.org/10.1111/jnc.15760

Krall, R., Gale, J. R., Ross, M. M., Tzounopoulos, T., & Aizenman, E. (2022). Intracellular zinc signaling influences NMDA receptor function by enhancing the interaction of ZnT1 with GluN2A. Neuroscience letters, 790, 136896. https://doi.org/10.1016/j.neulet.2022.136896

Gleixner, A. M., Verdone, B. M., Otte, C. G., Anderson, E. N., Ramesh, N., Shapiro, O. R., Gale, J. R., Mauna, J. C., Mann, J. R., Copley, K. E., Daley, E. L., Ortega, J. A., Cicardi, M. E., Kiskinis, E., Kofler, J., Pandey, U. B., Trotti, D., & Donnelly, C. J. (2022). NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility. Nature communications, 13(1), 3380. https://doi.org/10.1038/s41467-022-31098-6

Gale, J. R., Gedeon, J. Y., Donnelly, C. J., & Gold, M. S. (2022). Local translation in primary afferents and its contribution to pain. Pain, 163(12), 2302–2314. https://doi.org/10.1097/j.pain.0000000000002658

Gale, J. R., Kosobucki, G. J., Hartnett-Scott, K. A., & Aizenman, E. (2021). Imprecision in Precision Medicine: Differential Response of a Disease-Linked GluN2A Mutant to NMDA Channel Blockers. Frontiers in pharmacology, 12, 773455. https://doi.org/10.3389/fphar.2021.773455

Liu, H. Y., Gale, J. R., Reynolds, I. J., Weiss, J. H., & Aizenman, E. (2021). The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction. Biomedicines, 9(5), 489. https://doi.org/10.3390/biomedicines9050489

Snyder LM, Chiang MC, Loeza-Alcocer E, Omori Y, Hachisuka J, Sheahan TD, Gale JR, Adelman PC, Sypek EI, Fulton SA, Friedman RL, Wright MC, Duque MG, Lee YS, Hu Z, Huang H, Cai X, Meerschaert KA, Nagarajan V, Hirai T, Scherrer G, Kaplan DH, Porreca F, Davis BM, Gold MS, Koerber HR, Ross SE. Kappa Opioid Receptor Distribution and Function in Primary Afferents. Neuron. 2018 Sep 19;99(6):1274-1288.e6. doi: 10.1016/j.neuron.2018.08.044. PMID: 30236284; PMCID: PMC6300132.

Trainee Name: Geyon Garcia

Trainee: Current

Faculty Member: Lan Coffman, MD, PhD

Publications:

Atiya HI, Gorecki G, Garcia GL, Frisbie LG, Baruwal R, Coffman L. Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells. Biomolecules. 2023 Nov 1;13(11):1604. doi: 10.3390/biom13111604. PMID: 38002286; PMCID: PMC10669774.

Frisbie L, Pressimone C, Dyer E, Baruwal R, Garcia G, St Croix C, Watkins S, Calderone M, Gorecki G, Javed Z, Atiya HI, Hempel N, Pearson A, Coffman LG. Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer. Cell Rep. 2024 Aug 27;43(8):114551. doi: 10.1016/j.celrep.2024.114551. Epub 2024 Jul 26. PMID: 39067022; PMCID: PMC11420855.

Trainee Name: Joshua Garfein

Trainee: Current

Faculty Member: Jared Magnani, MD, MSc

Publications:

Garfein J, Guhl EN, Swabe G, Sekikawa A, Barinas-Mitchell E, Forman DE, Magnani JW. Racial and Ethnic Differences in Cardiac Rehabilitation Participation: Effect Modification by Household Income. J Am Heart Assoc. 2022 Jul 5;11(13):e025591. doi: 10.1161/JAHA.122.025591. Epub 2022 Jun 22. PMID: 35730601; PMCID: PMC9333381.

Sekikawa A, Wharton W, Butts B, Veliky CV, Garfein J, Li J, Goon S, Fort A, Li M, Hughes TM. Potential Protective Mechanisms of S-equol, a Metabolite of Soy Isoflavone by the Gut Microbiome, on Cognitive Decline and Dementia. Int J Mol Sci. 2022 Oct 7;23(19):11921. doi: 10.3390/ijms231911921. PMID: 36233223; PMCID: PMC9570153.

Irani S, Brandt EJ, Pai CW, Garfein J, Kline-Rogers E, Rubenfire M. Educational Attainment and Cardiovascular Risk Among Patients in Cardiac Rehabilitation. Am J Cardiol. 2023 Nov 15;207:465-469. doi: 10.1016/j.amjcard.2023.08.105. Epub 2023 Oct 7. PMID: 37804557.

Garfein J, Chen Y, Swabe G, Guhl E, Forman DE, Magnani JW. Race or ethnicity and education in cardiac rehabilitation enrollment. J Cardiol. 2024 Apr;83(4):280-283. doi: 10.1016/j.jjcc.2023.08.002. Epub 2023 Aug 8. PMID: 37562543; PMCID: PMC10850430.

Trainee Name: Shohini Ghosh-Choudhary, PhD

Trainee: Current

Faculty Member: Toren Finkel, MD, PhD

Publications:

Ghosh-Choudhary S, Liu J, Finkel T. Metabolic Regulation of Cell Fate and Function. Trends Cell Biol. 2020 Mar;30(3):201-212. doi: 10.1016/j.tcb.2019.12.005. Epub 2020 Jan 23. PMID: 31983571; PMCID: PMC7043867.

Ghosh-Choudhary SK, Liu J, Finkel T. The role of mitochondria in cellular senescence. FASEB J. 2021 Dec;35(12):e21991. doi: 10.1096/fj.202101462R. PMID: 34758157; PMCID: PMC8720272.

Ghosh-Choudhary S, Chan SY. Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension. Adv Exp Med Biol. 2021;1303:57-69. doi: 10.1007/978-3-030-63046-1_4. PMID: 33788187.

Liu J, Toy R, Vantucci C, Pradhan P, Zhang Z, Kuo KM, Kubelick KP, Huo D, Wen J, Kim J, Lyu Z, Dhal S, Atalis A, Ghosh-Choudhary SK, Devereaux EJ, Gumbart JC, Xia Y, Emelianov SY, Willett NJ, Roy K. Bifunctional Janus Particles as Multivalent Synthetic Nanoparticle Antibodies (SNAbs) for Selective Depletion of Target Cells. Nano Lett. 2021 Jan 13;21(1):875-886. doi: 10.1021/acs.nanolett.0c04833. Epub 2021 Jan 4. PMID: 33395313; PMCID: PMC8176937.

Ghosh-Choudhary, Shohini¹; Carleton, Neil²; Flynn, JoAnne L. PhD³; Kliment, Corrine R. MD, PhD⁴ Strategies for Achieving Gender Equity and Work–Life Integration in Physician-Scientist Training, Academic Medicine: July 20, 2021 - Volume - Issue - doi: 10.1097/ACM.0000000000004246

Moturi S, Ghosh-Choudhary SK, Finkel T. Cardiovascular disease and the biology of aging. J Mol Cell Cardiol. 2022 Jun;167:109-117. doi: 10.1016/j.yjmcc.2022.04.005. Epub 2022 Apr 11. PMID: 35421400.

Ghosh-Choudhary S, Carleton N, Nouraie SM, Kliment CR, Steinman RA. Predoctoral MD-PhD grants as indicators of future NIH funding success. JCI Insight. 2022 Mar 22;7(6):e155688. doi: 10.1172/jci.insight.155688. PMID: 35315356; PMCID: PMC8986062.

Ghosh-Choudhary S, Finkel T. Lactylation regulates cardiac function. Cell Res. 2023 Sep;33(9):653-654. doi: 10.1038/s41422-023-00857-5. PMID: 37488305; PMCID: PMC10474038.

Trainee Name: Gabrielle Gilmer, PhD

Trainee: Current

Faculty Member: Fabrisia Ambrosio, PhD, MPT

Publications:

Iijima H, Gilmer G, Wang K, Sivakumar S, Evans C, Matsui Y, Ambrosio F. Meta-analysis integrated with multi-omics data analysis to elucidate pathogenic mechanisms of age-related knee osteoarthritis in mice. J Gerontol A Biol Sci Med Sci. 2022 Jan 3:glab386. doi: 10.1093/gerona/glab386. Epub ahead of print. PMID: 34979545.

Kwan JM, Noch E, Qiu Y, Toubat O, Christophers B, Azzopardi S, Gilmer G, Wiedmeier JE, Daye D. The Impact of COVID-19 on Physician-Scientist Trainees and Faculty in the United States: A National Survey. Acad Med. 2022 Oct 1;97(10):1536-1545. doi: 10.1097/ACM.0000000000004802. Epub 2022 Sep 23. PMID: 35921163; PMCID: PMC9547818.

Gilmer G, Hettinger ZR, Tuakli-Wosornu Y, Skidmore E, Silver JK, Thurston RC, Lowe DA, Ambrosio F. Female aging: when translational models don't translate. Nat Aging. 2023 Dec;3(12):1500-1508. doi: 10.1038/s43587-023-00509-8. Epub 2023 Dec 5. Erratum in: Nat Aging. 2024 Jan;4(1):164. doi: 10.1038/s43587-023-00561-4. PMID: 38052933; PMCID: PMC11099540.

Gilmer G, Jackson N, Koscumb S, Marroquin OC, Sowa G. A Retrospective Analysis of Clinical Utilization Between Patients Who Used Telemedicine and Office Visits in Outpatient Physical Medicine and Rehabilitation Clinics During the COVID-19 Pandemic. Am J Phys Med Rehabil. 2023 Jan 1;102(1):34-42. doi: 10.1097/PHM.0000000000002012. Epub 2022 Mar 12. PMID: 35302527; PMCID: PMC9464794.

Khay AM, Gilmer G, Iijima H. Timely interventions: aerobic exercise and microvascular health post-menopause. J Physiol. 2024 Aug 30. doi: 10.1113/JP287073. Epub ahead of print. PMID: 39213462.