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Publications

Trainee Name: Jasmine Hect
Trainee: Current
Faculty Member: Taylor Abel, MD
Publications:

Ikegaya, N., Aung, T., Mallela, A., Hect, J.L., Damiani, A., Gonzalez-Martinez, J. (2024) Thalamic stereoencephalography for neuromodulation target selection: Proof of concept and review of literature of pulvinar direct electrical stimulation. Epilepsia. https://doi.org/10.1111/epi.17986 

Al-Ramadhani, R., Hect, J.L., Abel, T.J. (2024) The changing landscape of palliative epilepsy surgery for Lennox Gastaut Syndrome. Frontiers in Neurology. https://doi.org/10.3389/fneur.2024.1380423 

Hect, J.L., Mallela, A., Pupi, M., Anthony, A., Fogg, D., Ho, J., Slingerland, A., Ikegaya, N., Abou-Al-Shaar, H., Aung, T., Gonzalez-Martinez, J. (2024) Safety of concomitant cortical and thalamic sEEG explorations in patients with drug resistant epilepsies. Neurosurgery.   

Fields, D.P., Lavadi, R.S., Hudson, J.S., McCarthy, D.J., Hect, J.L., Wawrose, R., Capuk, O., Agarwal, N., McDowell, M., Simon, D., Abel, T.J., Greene, S. (2023) Patterns in follow-up imaging utilization for pediatric patients with whiplash associated disorder. World Neurosurgery. https://doi.org/10.1016/j.wneu.2023.10.048 

Gatesman, T.A., Hect, J.L., Phillips, H.W., McClung, C., Nikiforov, Y.E., Nikiforova, M.N., Pollack, I.F., Agnihotri, S., Abel, T.J. (2023) Characterizations of low-grade epilepsy associated tumor from implanted stereoelectroencephalography electrodes. Epilepsia Open. https://doi.org/10.1002/epi4.12840 

Hect, J.L, Sefcik, R.K., Nowicki, K.W., Katz, J., Greene, S. (2023) Case series: Serial neuroendoscopy for the treatment of elevated cerebrospinal fluid protein levels in infants with Gram-negative rod ventriculitis. Pediatric Neurosurgery. https://doi.org/10.1159/000534083  

Phillips, W.H., Hect, J.L., Harford, E., Pan, E., Abel, T.J. (2023) Comparison of magnetic resonance guided laser interstitial thermal therapy corpus callosum ablation (CCA) to open microsurgical corpus callosotomy: A single center retrospective cohort study. Epilepsia Open. https://doi.org/10.1002/epi4.12835 

Hect, J.L., Harford, E., Maroufi, S.F., Klem, M.L., Mansouri, S.A., Abel, T.J. (2023) Clinical outcomes of MR-guided laser interstitial thermal therapy corpus callosum ablation in drug-resistant epilepsy: A systematic review and meta-analysis. JNS: Pediatrics.  https://doi.org/10.3171/2023.9.PEDS23326 

Van den Heuvel, M., Monk, C., Hendrix, C.L., Hect, J.L., Lee, S., Feng, T., Thomason, M.E. (2023) Intergenerational transmission of maternal childhood maltreatment prior to birth: effects on human fetal amygdala functional connectivity. Journal of the American Academy of Child & Adolescent Psychiatry. https://doi.org/10.1016/j.jaac.2023.03.020  

 Hect, J.L., McDowell, M.M., Fields, D., Greene, S. (2023) Relationship of cervical soft tissue injury and surgical prediction following pediatric cervical spine trauma and its sequelae on long-term neurologic outcome. World Neurosurg X. https://doi.org/10.1016/j.wnsx.2023.100235 

 Luther, E., McCarthy, D., Hect, J.L., Burks, J., Lu, V.M., Govindarajan, V., Ramsay, I.A., King, H., Silva, M.A. Abdelsalam, A., Yavagal, D., Peterson, E., Starke, R., Morcos, J. (2023) Transradial access failures during neuroangiography for patients with Moyamoya. Neurosurgery. https://doi.org/10.1227/neu.0000000000002421 

Hect, J.L., Almast, A., Simon, D., Shoemaker, S., McDowell, M.M. (2023) Prevalence, severity, and neurosurgical management of abusive head trauma during the COVID-19 pandemic. Journal of Neurosurgery: Pediatrics 1, 1-7. https://doi.org/10.3171/2023.2.PEDS2317 

 Abel, T.J., Muthiah, N., Hect, J.L., Gonzalez-Martinez, J., Salehi, A., Smyth, M., Smith, K.J. (2022) Cost-effectiveness of invasive monitoring strategies in epilepsy surgery. Journal of Neurosurgery 1, 1–7. https://doi.org/10.3171/2022.11.JNS221744 

 Andrews, T., Hect, J.L., Mittal, A., Nowicki, K., Agarwal, V., Gerstzen, P. (2022) Tetra-compartmental spinal infection with conus medullaris syndrome: a case report. JNS: Case Lessons. https://doi.org/10.2171/CASE22447 

 Greene, S., Hect, J.L., McDowell, M. (2022) Letter to the Editor: Comparison of Follow-Up Length-Matched Single-Center Myelomeningocele Postnatal Closure Cohort to the Management of Myelomeningocele Study (MOMS) Trial Results. Pediatr Neurosurg 58, 61–64. https://doi.org/10.1159/000529013 

 Rhone, A.E., Rupp, K.M., Hect, J.L., Harford, E.E., Tranel, D., Howard, M.A. III, Abel, T.J. (2022) Electrocorticography reveals the dynamics of famous voice responses in human fusiform gyrus. J Neurophysiol. https://doi.org/10.1152/jn.00459.2022 

 Curtis, K., Hect, J.L., Harford, E., Welch, W.P., Abel, T.J. (2022) Responsive neurostimulation for pediatric drug resistant epilepsy: a case series and review of the literature. Neurosurg Focus. https://doi.org/10.3171/2022.7.FOCUS22331 

 Rupp, K., Hect, J.L., Remick, M., Ghuman, A., Chandrasekaran, B., Holt, L.L., Abel, T.J. (2022) Neural responses in human superior temporal cortex support coding of voice representations. PLOS Biology. https://doi.org/10.1371/journal.pbio.3001675 

 Bhatia, A., Lee, V.K., Qian, Y., Paladino, M., Ceschin, R., Hect, J.L., Mountz, J., Sun, D., Kohanbash, G., Pollack, I., Jakacki, R., Boada, F., Panigrahy A. (2022) Quantitative sodium (23Na) MRI in pediatric brain tumors treated with immunotherapy: Initial experience. Diagnostics. https://doi.org/10.3390/diagnostics12051223 

 Hect, J.L.*, Alattar, A.A.*, Reecher, H., Harford, E., Fernandes, D.T., Esplin, N., McDowell, M., Abel, T.J., (2021) Stereotactic laser interstitial thermal therapy for the treatment of pediatric drug-resistant epilepsy: Indications, techniques, and safety. Child’s Nervous System. https://doi.org/10.1007/s00381-022-05491-x 

 Hect, J.L., Welch, W., Fernandez, L.,Abel, T.J. (2021) Deep brain stimulation of the centromedian nucleus for the treatment of status epilepticus in a patient with FIRES. Epilepsia Open. https://doi.org/10.1002/epi4.12568 

Hect, J.L.*, Mallela, A.N*, Abou-Al-Shaar, H., Akwayena, E., Abel, T.J. (2021) Stereotactic laser interstitial thermal therapy corpus callosotomy for the treatment of atonic seizures in pediatric refractory epilepsy. Epilepsia Open. https://doi.org/10.1002/epi4.12559 

 Thomason, M.E., Hect, J.L., Waller, R., Curtin, P. (2021) Interactive relations between maternal prenatal stress, fetal brain connectivity and delivery timing. Neuropsychopharmacology.  
https://doi.org/10.1038/s41386-021-01066-7 

 Welch, W., Hect, J.L., Abel, T.J., (2021) Case report: Responsive neurostimulation of the centromedian thalamic nucleus for the detection and treatment of seizures in pediatric primary generalized epilepsy. Frontiers Neurology. https://doi.org/10.3389/fneur.2021.656585 

Trainee Name: Victoria Heinrich PhD
Trainee: Current
Faculty Member: Alison Morris, MD, MS
Publications:
Heinrich VA, Uvalle C, Manni ML, Li K, Mullett SJ, Donepudi SR, Clader J, Fitch A, Ellgass M, Cechova V, Qin S, Holguin F, Freeman BA, Methé BA, Morris A, Gelhaus SL. Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma. Front Microbiomes. 2023;2:1153691. doi: 10.3389/frmbi.2023.1153691. Epub 2023 May 5. PMID: 37293566; PMCID: PMC10249466.

Santos-Lopez A, Fritz MJ, Lombardo JB, Burr AHP, Heinrich VA, Marshall CW, Cooper VS. Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply. Evol Med Public Health. 2022 May 30;10(1):266-276. doi: 10.1093/emph/eoac022. PMID: 35712084; PMCID: PMC9198447.

Manni ML, Heinrich VA, Buchan GJ, O'Brien JP, Uvalle C, Cechova V, Koudelka A, Ukani D, Rawas-Qalaji M, Oury TD, Hart R, Ellgass M, Mullett SJ, Fajt ML, Wenzel SE, Holguin F, Freeman BA, Wendell SG. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Sci Rep. 2021 Sep 7;11(1):17788. doi: 10.1038/s41598-021-96471-9. PMID: 34493738; PMCID: PMC8423735.

Trainee Name: Ruby Holland PhD
Trainee: Current
Faculty Member: Alan Sved, PhD
Publications:

Nguyen E, Smith KM, Cramer N, Holland RA, Bleimeister IH, Flores-Felix K, Silberberg H, Keller A, Le Pichon CE, Ross SE. Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit. Brain. 2022 Jul 29;145(7):2586-2601. doi: 10.1093/brain/awac189. PMID: 35598161.

Holland RA, Ross SE. Beyond lidocaine: selective voltage-gated sodium channel blockade for vaginal pain. Pain. 2021 Jan;162(1):1-3. doi: 10.1097/j.pain.0000000000002037. PMID: 32773604.

Trainee Name: Bryan Hurtle, PhD
Trainee: Current
Faculty Member: Christopher J Donnelly, PhD
Publications:

Mann JR, Gleixner AM, Gomes E, DeChellis-Marks MR, Needham PG, Hurtle B, Portz B, Mauna JC, Calder CB, Copley KE, Wills ZP, Pandey UB, Brodsky JL, Thathiah A, Shorter J, Donnelly, CJ. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. (2019) Neuron. 102:321-338.

Huang Y, Rafael Guimarães T, Todd N, Ferguson C, Weiss KM, Stauffer FR, McDermott B, Hurtle BT, Saito T, Saido TC, MacDonald ML, Homanics GE, Thathiah A. G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2204828119. doi: 10.1073/pnas.2204828119. Epub 2022 Sep 26. PMID: 36161942; PMCID: PMC9546571.
 
Hurtle BT, Xie L, Donnelly CJ. Disrupting pathologic phase transitions in neurodegeneration. J Clin Invest. 2023 Jul 3;133(13):e168549. doi: 10.1172/JCI168549. PMID: 37395272; PMCID: PMC10313377.
 
Hurtle B, Donnelly CJ, Zhang X, Thathiah A. Live-cell visualization of tau aggregation in human neurons. Commun Biol. 2024 Sep 14;7(1):1143. doi: 10.1038/s42003-024-06840-z. PMID: 39277689; PMCID: PMC11401922.
 
Xie L, Merjane J, Bergmann CA, Xu J, Hurtle B, Donnelly CJ. CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function. bioRxiv [Preprint]. 2024 Jul 12:2024.07.12.603231. doi: 10.1101/2024.07.12.603231. PMID: 39026766; PMCID: PMC11257528.
Trainee Name: Deepa Issar
Trainee: Current
Faculty Member: Matthew Smith, PhD
Publications:

Snyder AC, Issar D, Smith MA. What does scalp electroencephalogram coherence tell us about long-range cortical networks? Eur J Neurosci. 2018 Oct;48(7):2466-2481. doi: 10.1111/ejn.13840. Epub 2018 Feb 13. PMID: 29363843; PMCID: PMC6497452.

Issar D, Williamson RC, Khanna SB, Smith MA. A neural network for online spike classification that improves decoding accuracy. J Neurophysiol. 2020 Apr 1;123(4):1472-1485. doi: 10.1152/jn.00641.2019. Epub 2020 Feb 26. PubMed PMID: 32101491.

Johnston R, Snyder A, Khanna S, Issar D, Smith M. The eyes reflect an internal cognitive state hidden in the population activity of cortical neurons. [preprint]. 2020 June; doi: 10.1101/2020.06.29.178251.

 

Trainee: Current
Faculty Member: Angela Gronenborn, PhD
Publications:
Xie Y, Clarke BP, Kim YJ, Ivey AL, Hill PS, Shi Y, Ren Y. Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2. Elife. 2021 Mar 31;10:e65699. doi: 10.7554/eLife.65699. PMID: 33787496; PMCID: PMC8043747.
 
Sun D, Sang Z, Kim YJ, Xiang Y, Cohen T, Belford AK, Huet A, Conway JF, Sun J, Taylor DJ, Schneidman-Duhovny D, Zhang C, Huang W, Shi Y. Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes. Nat Commun. 2021 Aug 3;12(1):4676. doi: 10.1038/s41467-021-24963-3. PMID: 34344900; PMCID: PMC8333356.
 
Yong Joon Kim J, Sang Z, Xiang Y, Shen Z, Shi Y. Nanobodies: Robust miniprotein binders in biomedicine. Adv Drug Deliv Rev. 2023 Apr;195:114726. doi: 10.1016/j.addr.2023.114726. Epub 2023 Feb 7. PMID: 36754285.
 
Krzysiak TC, Choi YJ, Kim YJ, Yang Y, DeHaven C, Thompson L, Ponticelli R, Mermigos MM, Thomas L, Marquez A, Sipula I, Kemper JK, Jurczak M, Thomas G, Gronenborn AM. Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification. Protein Sci. 2024 Apr;33(4):e4938. doi: 10.1002/pro.4938. PMID: 38533551; PMCID: PMC10966392.
Trainee Name: Anna Kirillova
Trainee: Current
Faculty Member: Stephen Chan, MD, PhD, FAHA
Publications:

Kirillova A, Han L, Liu H, Kühn B. Polyploid cardiomyocytes: implications for heart regeneration. Development. 2021 Jul 15;148(14):dev199401. doi: 10.1242/dev.199401. Epub 2021 Jul 26. PMID: 34897388; PMCID: PMC8326922.

Kirillova A, Chan SY. miR-roring Changes in Blood: miR-210 Reflects Hypoxic Disease Dynamics in Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2022 Oct 6. doi: 10.1164/rccm.202209-1709ED. Epub ahead of print. PMID: 36201758.

Trainee: Current
Faculty Member: Janet Catov, PhD
Publications:

Medina-Rivera M, Centeno-Tablante E, Finkelstein JL, Rayco-Solon P, Peña-Rosas JP, Garcia-Casal MN, Rogers L, Ridwan P, Martinez SS, Andrade J, Layden AJ, Chang J, Zambrano MP, Ghezzi-Kopel K, Mehta S. Presence of Ebola virus in breast milk and risk of mother-to-child transmission: synthesis of evidence. Ann N Y Acad Sci. 2020 Oct 28. doi: 10.1111/nyas.14519. Epub ahead of print. PMID: 33113592.

Layden A, 2018, B-Vitamins and HIV/AIDS, Nutrition and HIV/AIDS.

Layden A, Täse K, Finkelstein J, 2018, Neglected tropical diseases and vitamin B12: a review of the current evidence, Transactions of the Royal Society of Tropical Medicine and Hygiene, 112:423-435.

Finkelstein J, Colt S, Layden A, Krisher J, Stewart-Ibarra A, Polhemus M, Beltrán-Ayala E, Tedesco J, Cárdenas W, Endy T, Mehta S, 2020, Micronutrients, Immunological Parameters, and Dengue Virus Infection in Coastal Ecuador: A Nested Case-Control Study in an Infectious Disease Surveillance Program, The Journal of infectious diseases, 221:91-101.

Trainee Name: Danica Lee
Trainee: Current
Faculty Member: Daniella Schwartz, MD
Publications:

Anthony-Gonda K, Ray A, Su H, Wang Y, Xiong Y, Lee D, Block A, Chilunda V, Weiselberg J, Zemelko L, Wang YY, Kleinsorge-Block S, Reese JS, de Lima M, Ochsenbauer C, Kappes JC, Dimitrov DS, Orentas R, Deeks SG, Rutishauser RL, Berman JW, Goldstein H, Dropulić B. In vivo killing of primary HIV-infected cells by peripheral-injected early memory-enriched anti-HIV duoCAR T cells. JCI Insight. 2022 Nov 8;7(21):e161698. doi: 10.1172/jci.insight.161698. PMID: 36345941; PMCID: PMC9675454.

Trainee Name: Brandon Lehrich
Trainee: Current
Faculty Member: Pal Monga, MD
Publications:

Lehrich BM, Tao J, Liu S, Hirsch TZ, Yasaka TM, Cao C, Delgado ER, Guan X, Lu S, Pan L, Liu Y, Singh S, Poddar M, Bell A, Singhi AD, Zucman-Rossi J, Wang Y, Monga SP, Development of Mutated β-catenin Gene Signature to identify CTNNB1 mutations from whole and spatial transcriptomic data in patients with HCC, JHEP Reports, https://doi.org/10.1016/j.jhepr.2024.101186.